当前位置: 首页 >> 师资队伍 >> 制药工程方向 >> 正文
周宇涵副教授
 

 

 

   姓名:周宇涵 副教授 

  
   办公电话:84986186


   邮箱:zhouyh@dl.cn

 

 

 

主要学历及工作简历:
1993.09-1997.07 大连理工大学精细化工系  本科
1997.09-2000.03 大连理工大学精细化工系  硕士研究生
2000.03-2003.02 大连理工大学精细化工系  博士研究生
2003.03-2010.02 大连理工大学精细化工系  讲师、副教授
2009.02-2010.01 法国巴黎第五大学药学院  博士后
2010.03-至今  大连理工大学制药科学与技术学院,副教授


主要学术及社会实践:
学术期刊《Pharmacologia》、《有机化学研究》、《药物资讯》编委。

研究方向:
药物合成;
有机合成新方法研究;
不对称催化;
金属有机化学;


研究课题:
1.国家自然科学基金:杂环Protox 抑制剂的结构设计、合成与生物活性研究,2007.1-2009.12;
2.先正达公司合作项目:除草活性化合物合成,2010.5-2011.6;
3.国家自然科学基金面上项目:金属络合物催化的高选择性三氟乙酸酯酮交换反应研究,2014.1-2017.12;
4.国家自然科学基金面上项目:铁催化烯烃的硼化反应及其机理研究, 2016.1-2019.12;


出版著作和论文:

1] Yang Liu, Yuhan Zhou, Huan Wang and Jingping Qu. FeCl2-Catalyzed Hydroboration of Aryl Alkenes with Bis(pinacolato)diboron. RSC Adv. 2015, 5, 73705-73713.
[2] Xiaoliang Dong, Litao Liu, Yuhan Zhou, Jun Liu, Yixin Zhang, Yanhui Chen, and Jingping Qu. Synthesis of Carboxylate-bridged Iron-thiolate Clusters from Alcohols/Aldehydes or Carboxylate salts. Dalton Trans. 2015, 44, 14952-14958.
[3] Xiaoliang Dong, Yuhan Zhou?, Yuming Song, Jingping Qu. Anthracene-Fe3+ ensemble based turn-on fluorescent probes for selective detection of fluoride. J. Fluorine Chem. 2015, 178, 61-67.
[4] Dongmei Yang, Yuhan Zhou?, Yuming Song, Jingping Qu. A practical synthesis of trifluoromethyl alkyl ketones. J. Fluorine Chem. 2015, 173, 6-11.
[5] Yuhan Zhou, Yuming Song, Yang Liu, and Jingping Qu. A convenient one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC 2015 (v), 99-109.
[6] Weiguo Song, Liangjun Dong, Yuhan Zhou, Yongqiang Fu, Wenfang Xu. Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77.
[7] Yuhan Zhou, Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo, Na Xue, Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31), 4668-4674.
[8] Yuhan Zhou, Guchao Gao, Yuming Song, Jingping Qu. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. Synth. Commun., 2014, 44(10), 1515-1520.
[9] 杨冬梅,周宇涵*,常晴,赵一龙,曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986.
[10] Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao. Reversible photoswitching of triplet-triplet annihilation upconversion using dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259.
[11] Dongmei Yang, Yuhan Zhou, Na Xue, Jingping Qu. Synthesis of Trifluoromethyl Ketones via Tandem Claisen Condensation and Retro-Claisen C?C Bond-Cleavage Reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)
[12] Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Chunmei Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu. Synthesis, structure and reactions of triply selenolate-bridged diiron complex [Cp*Fe(μ-SeMe)3FeCp*]. Inorg. Chem. Commun. 2013, 29, 179-182.
[13] Weiguo Song, Yuhan Zhou, Yongqiang Fu, Wenfang Xu. Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16), 909-912.
[14] Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong, Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia Formation by a Thiolate-Bridged Diiron Amide Complex as a Nitrogenase Mimic. Nature Chem. 2013, 5(4), 320-326.
[15] Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui Chen, Jingping Qu. Synthesis and Characterization of a Thiolate-bridged Diiron Complex with Two Monocoordinated Azido Ligands: [Cp*Fe(μ-SMe)N3]2 (Cp* = η5-C5Me5). Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087.
[16] 徐珊珊,周宇涵,曲景平. CuOTf/NNN三齿钳形配体催化不对称Henry反应. 有机化学, 2012, 32(7), 1131-1135.
[17] Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou, Jingping Qu*. Highly Enantio- and Diastereoselective Vinylogous Aldol Reaction by LiCl-Assisted BINOL―Titanium Species,Org. Lett. 2012, 14, 2734-2737.
[18] 董晓亮,周宇涵,徐珊珊,曲景平. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026.
[19] 赵金凤,窦海建,周宇涵,曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报,2011, 32 (10), 2331-2334.
[20] Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14), 2607-2610 (Synfacts 2010, 6, 0704).
[21] Yuhan Zhou, Na Xue, Guowei Wang, Jingping Qu. Synthesis, Structure and Herbicidal Activity of Substituted Phenyl Pyrazole Derivatives. J. Chem. Res.2010, 34(12), 684-688.
[22] Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu. Mild and Highly Enantioselective Vinylogous Aldol Reaction of Brassard’s Diene with Aromatic Aldehydes by Combined Lewis Acid Catalyst. J. Org. Chem. 2010, 75(15), 5326-5329 (Synfacts 2010, 6, 1266).
[23] Yuhan Zhou, Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis, Structures and Herbicidal Activity of Isoxazole Derivatives. J. Heterocyclic Chem. 2010, 47(6), 1310-1316.
[24] Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly Efficient and Regioselective Allylic Amination of Allylic Alcohols Catalyzed by [Mo3PdS4] Cluster. Tetrahedron Lett. 2010, 51, 1982-1984.
[25] Na Xue, Yuhan Zhou, Guowei Wang, Weirong Miao, Jingping Qu. Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J. Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010).
[26] Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu, Masanobu Hidai. Heterometallic cubane-type clusters [MMo3S4] (M = Au, Ag and Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39, 5658 – 5663.
专著
[27] Yuhan Zhou*, Xiaoliang Dong, Jingping Qu. Synthesis, structure and herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications (Chapter 13) USA: Nova Science Publishers, 2013, 263-276 (2013-12).
[28] Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Ko?mrlj.) Springer-Verlag Berlin Heidelberg: 2012, 185-232.
[29] 李和平,周宇涵,冯光柱,申艳敏,黄雪,刘云,袁超,何利霞. 含氟溴碘精细化学品. 北京:化学工业出版社,2010-09-01.(“十一五国家重点图书”)
[30] 李和平,冯光柱,魏文珑,孙建军,周宇涵,黄雪. 含氯精细化学品. 北京:化学工业出版社,2010-08-01. (“十一五国家重点图书”)


 

 

上一条:程昉副教授
下一条:王保民教授
关闭窗口